Parasitologia hungarica

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Author(s): Kemenes, F. & Horváth, Gy.
Title: The pathogenicity of Trypanosoma equiperdum to different rodents. I. Susceptibility of laboratory white mice and rats
Title: A Trypanosoma equiperdum különböző rágcsálókkal szembeni fertőzőképessége. I. A laboratóriumi fehér egér és patkány fogékonysága
Year: 1986
Volume: 19
Pages: 19-26.

Abstract: The parenteral inoculation of Trypanosoma equiperdum strain induces fatal septicaemia with a 2- to 5-fold enlargement of the spleen. Intraperitoneally inoculated white mice and rats died sooner and more uniformly than those inoculated subcutaneously. Inbred mice (7 different strains) were as susceptible as the conventional Swiss mice. Mice being in an advanced stage of pregnancy and having a greater body mass died one or two days later. However, in their offspring delivered before term trypanosomes were not demonstrable. The fatal septicaemia of susceptible mice could be prolonged with 2 to 4 days if they were given antitrypanosomal rabbit immune sera or convalescent sera of resistant rodents. Infection did not even take place in the presence of high antibody levels. Rats are as susceptible as mice are. To produce trypanoaome antigen, it is advisable to inoculate rats with 1000000-10000000 trypanosomes subcutaneously.
Keywords: Trypanosoma equiperdum, mouse, rat, susceptibility, survival prolongation

Journal: Parasitologia Hungarica
Journal abbreviation:
ISSN: 0303-688X
Publisher: Népművelési Propaganda Iroda, Budapest
Editor(s): K. Murai, É., Thoma, A. & Nemes, I.