Parasitologia hungarica

Author(s): Axmann, Á. & Anh, T. K.
Title: Treatment of chloroquine-resistant Plasmodium falciparum malaria by a combination of quinine and quinidine
Title: Chloroquine-rezisztens maláriában (Plasmodium falciparum) szenvedő betegek eredményes kezelése quinine and quinidine kombinációjával
Year: 1993
Volume: 26
Pages: 5-10.

Abstract: The increasing number of chloroquine-resistant Plasmodium falciparum (Pf.) malaria cases made it necessary to look for a new therapeutic agent effective against this life-threatening disease. The excellent antimalarial effect of quinidine proven in vitro by several authors from Thailand gave us the idea to use it for an in vivo study. The aim of this study was to find the ideal dose of quinidine for malaria treatment, to avoid or diminish its effects on the heart while keeping its antimalarial efficacy. The solution was found in a combination of quinidine with his stereoisomer quinine, where the synergy of the parent compounds allowed a dose reduction of quinidine while keeping its antimalarial effects.
Keywords: treatment, Plasmodium falciparum, malaria, chloroquine resistance, quinine, quinidine

Journal: Parasitologia Hungarica
Journal abbreviation:
ISSN: 0303-688X
Publisher: Magyar Parazitológusok Társasága, Budapest
Editor(s): K. Murai, É. & Thoma, A.